Relationship between LECT2 and diabetic microvascular complications

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790938
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Research Institute, International Medical Center of Japan
• Principal Investigator: OKUMURA Akinori 独立行政法人国立国際医療研究センター, その他部局等, その他 (90392357)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖尿病 / 細小血管障害 / 肥満 / LECT2

Outline of Final Research Achievements

Leukocyte cell-derived chemotaxin 2 (LECT2) is an anti-inflammatory molecule expressed in the liver. However, the clinical relevance of LECT2 in obesity and diabetes is unknown. The objective of this study was to determine whether serum LECT2 levels are affected by of obesity, diabetes, and its microvascular complications. A cross sectional study comprising 493 subjects were tested for LECT2 using a highly sensitive assay. The present study indicates that serum LECT2 levels are increased by obesity and decreased in diabetic retinopathy. These results suggest that LECT2 is a novel obesity-related protein and associated with the presence of diabetic retinopathy.

Free Research Field

細胞生物学