2013 Fiscal Year Final Research Report
Identification of new targets for metabolic syndrome via brown adipocytes
| Project/Area Number |
24790940
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 褐色脂肪細胞 / 分化制御因子 / バイオマーカー |
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| Research Abstract |
Fortunately, we could get two brown adipogenic cell lines and identify new pro-brown adipogenic gene A by microarray and knockdown analysis during brown adipocyte differentiation.
To address the new secretory proteins in mature adipocytes, we performed secretory protein profiling in mature brown and white adipocytes in the presence or absence of cAMP, glucagon signaling mimetics. This protein profiling analysis showed that cyclophilin A were secreted from both brown and white adipocytes in response to glucagon mimetic signaling.
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