The study of regulatory mechanisms on ghrelin secretion

2014 Fiscal Year Final Research Report

• Project/Area Number: 24790941
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Saitama University
• Principal Investigator: SAKATA Ichiro 埼玉大学, 理工学研究科, 准教授 (80610831)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: グレリン

Outline of Final Research Achievements

In this study, it has found that these cells express high levels of mRNA encoding G-protein coupled receptor 120 (GPR120). Addition of GW9508 (a GPR120 chemical agonist) and α-linolenic acid (a natural ligand for GPR120) inhibited the secretion of ghrelin. However, the expression levels of preproghrelin and ghrelin O-acyltransferase (GOAT) mRNAs were not influenced by GW9508. Pretreatment with GW-9508 blocked the effect of the norepinephrine (NE)-induced ghrelin elevation in ghrelin cell lines, and GW-9508 inhibited ghrelin secretion via extracellular signal-regulated kinase activity in ghrelin cell lines. These results indicate that the decrease of ghrelin secretion after feeding is induced partially by long-chain fatty acids.

Free Research Field

内分泌学