2013 Fiscal Year Final Research Report
Role of leptin signaling in regulation of immune cell functions.
| Project/Area Number |
24790942
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TANAKA Miyako 東京医科歯科大学, 医歯(薬)学総合研究科, メディカルフェロー (60622793)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | レプチン / 栄養 / 飢餓 / 免疫 / 炎症 |
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| Research Abstract |
Obesity is a state of chronic, low grade inflammation; it is characterized by increased infiltration of a variety of immune cells into obese adipose tissue. In contrast, nutritional deprivation or malnutrition suppresses immune function, thereby conferring higher susceptibility to infectious diseases. In this study, we focused on leptin, a major adipocyte-derived bioactive substance that is produced in response to the nutritional status, and investigated the role of leptin in the regulation of immune function or inflammation. Leptin deficiency caused impairment of B-cell development in the bone marrow, without affecting monocyte development. On the other hand, CCR2 expression in bone marrow cells was upregulated by obesity, suggesting that leptin induces inflammatory changes of bone marrow cells. These observations suggest that leptin may regulate immune cell functions in response to nutritional status.
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Author(s)
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Journal Title
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Volume: 63
Pages: 152-161
DOI
Peer Reviewed
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Journal Title
Diabetes
Volume: 61
Pages: 2442-2450
URL
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