2014 Fiscal Year Final Research Report
Investigate the role of ErbBs in pituitary adenoma
| Project/Area Number |
24790945
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 内分泌学 / 分子標的薬 / 腫瘍学 / 細胞周期 / 転写因子 |
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| Outline of Final Research Achievements |
There are only to kind of drugs available for pituitary adenomas, including dopamin agonist and somatostatin analog. And surgical treatment is the first choice for the tumors except prolactinomas. We have reported the EGF receptor as a therapeutic target for pituitary adenomas. In this project, we investigated the family of EGF receptor, namely ErbBs in detail. We found ErbB4, especially in Cushing's disease, could be a rarget to suppress the hormone synthesis and secretion from the tumors. This result could be an further development of new drug for these disease.
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| Free Research Field |
内分泌代謝
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