2014 Fiscal Year Final Research Report
Elucidation of glucocorticoid-induced overeating and obesity
| Project/Area Number |
24790947
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | グルココルチコイド / AgRP / 肥満 / 過食 |
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| Outline of Final Research Achievements |
In this study ,We revealed the mechanism of glucocorticoid induced overeating and obesity by considering expression of AgRP, POMC and NPY gene known as appetite-related gene. We produced CRH-Leptin double knockout(DKO, glucocorticoid absence) mice and compared to ob/ob mice(leptin knockout mice) about food intake, fat weight and hypothalamus appetite-related gene.
In this study , the DKO mice showed less eating and obesity compared to ob/ob mice. And in hypothalamus, the expression of AgRP mRNA of DKO mice was significantly reduced compared to ob/ob mice. This study showed AgRP gene in hypothalamus has important role about glucocorticoid induced overeating and obesity.
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| Free Research Field |
グルココルチコイドによる肥満・過食
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