2013 Fiscal Year Final Research Report
Development of the high blood pressure medical treatment by angiotensin receptor binding molecule
| Project/Area Number |
24790950
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | レニンアンジオテンシン / 受容体 / 高血圧 / 動脈硬化 / 尿細管 |
|---|
| Research Abstract |
We paid our attention to the functional role of renal tubule ATRAP in vivo, and, using renal tubule ATRAP overexpression transgenic mice, we examined functional role of renal tubule ATRAP in blood pressure regulation in response to pathologic stimulation. As a result, while ATRAP, with a high endogenous expression in renal tubules, preserves baseline physiological AT1R signaling activity, it would suppress pathological overactivation of AT1R signaling under pathological conditions. Furthermore, using vascular ATRAP overexpression transgenic mouse, we demonstrated that vascular ATRAP can suppress oxidative stress at local tissue sites and inhibit arteriosclerosis under pathological conditions.
|
Research Products
(18 results)
-
[Journal Article] Effects of Ang II Receptor Blocker, Irbesartan, on Adipose Tissue Function in Mice with Metabolic Disorders2014
Author(s)
Maeda A, Wakui H, et al. Ohsawa M, Azushima K, Uneda K, Kobayashi R, Tsurumi-Ikeya Y, Kanaoka T, Dejima T, Haku S, Yamashita A, Umemura S
-
Journal Title
Int J Mol Sci
Volume: 27;11(6)
Pages: 646-51
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
