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2014 Fiscal Year Final Research Report

The study of inflammasome activation system in endocrine and metabolic disorder models.

Research Project

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Project/Area Number 24790951
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionJichi Medical University

Principal Investigator

KAWASHIMA Akira  自治医科大学, 医学部, ポストドクター (60624913)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords分解 / ユビキチン / インフラマソーム
Outline of Final Research Achievements

The purpose of this study is to identify the inflammasome activation system. Firstly we performed comprehensive analysis of inflammasome components by TOF-MS. In result we found that certain type of E3 ubiquitin ligase binds one of the inflammasome components and ubiquitination. And this molecule inhibits inflammasome activation through degradation of inflammasome components. These results reveal the pathway that regulates the inflammasome through the ubiquitination and degradation.

Free Research Field

免疫学

URL: 

Published: 2016-06-03  

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