2013 Fiscal Year Final Research Report
Investigation of biomarkers that enable early diagnosis of graft-versus-host disease
| Project/Area Number |
24790960
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KURITA Naoki 筑波大学, 医学医療系, 講師 (30555561)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 移植片対宿主病 / Notchシグナル / 移植片対腫瘍効果 / 同種造血幹細胞移植 |
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| Research Abstract |
Graft-versus-host disease (GVHD) is a fatal complication of allogeneic stem-cell transplantation (allo-SCT). GVHD-model mice showed that Notch signaling of lymphocytes exacerbates GVHD. Therefore we conducted comprehensive analysis of Notch expression on lymphocytes after allo-SCT by using human samples. As a result, Notch1 was expressed only on NK cells and the expression was significantly higher in recipients of cord-blood transplantation. Not GVHD exacerbation, but reduction of relapse was seen in the recipients whose NK cells expressed Notch1 strongly. This result showed the possibility that enhancing graft-versus-tumor effect without worsening GVHD by manipulating Notch signal.
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