2013 Fiscal Year Final Research Report
Restoration of Treg homeostasis with Low-dose IL-2 administiration for patients with refractory chronic GVHD
| Project/Area Number |
24790975
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | GVHD / 制御性T細胞 / 免疫寛容 / インターロイキン２ |
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| Research Abstract |
CD4+CD25+Foxp3+ regulatory T cell (Treg) has a central role in maintaining immune tolerance and interleukin-2 (IL-2) is critical for Treg growth, survival and activity. We reported that administration of low-dose IL-2 could preferentially enhance Treg in vivo and suppress clinical manifestations of chronic GVHD after allogeneic hematopoietic stem cell transplantation, suggesting the therapeutic potential of low-dose IL-2 to reconstruct immune tolerance in vivo. Our murine experiments of low-dose IL-2 therapy demonstrated that in vivo effect of exogenous IL-2 is susceptible to several external factors, including the host immune status and the dose or timing of IL-2 administration. These findings will be important information to explore the individualized IL-2 therapy that enables to standardize and optimize this cytokine therapy.
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[Journal Article] mTOR inhibitors permit regulatory T cell reconstitution and inhibit chronic GVHD2014
Author(s)
Sugiyama H, Maeda Y, Nishimori H, Yamasuji Y, Matsuoka K, Fjii N, Kondo E, Shinagawa K, Takeuchi K, Teshima T, and Tanimoto M
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Journal Title
Biol Blood Marrow Transplant
Volume: 20(2)
Pages: 183-91
DOI
Peer Reviewed
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[Journal Article] Bronchiolitis obliterans with allogeneic hematopoietic cell transplantation : a 10-year experience of the Okayama BMT Group2014
Author(s)
Fujii N, Nakase K, Asakura S, Matsuo K, Nawa Y, Sunami K, Nishimori H, Matsuoka K, Kondo E, Maeda Y, Shinagawa K, Hara M, Tanimoto M
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Journal Title
Int J Hematol
Volume: 99(5)
Pages: 644-51
DOI
Peer Reviewed
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[Journal Article] Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease2013
Author(s)
Matsuoka K, Koreth J, Kim HT, Bascug G, McDonough S, Kawano Y, Murase K, Cutler C, Ho VT, Alyea EP, Armand P, Blazar BR, Antin JH, Soiffer RJ, Ritz J
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Journal Title
Sci Transl Med
Volume: 5(179)
Pages: 179ra43
DOI
Peer Reviewed
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[Journal Article] CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells2013
Author(s)
Naito M, Hainz U, Burkhardt UE, Fu B, Ahove D, Stevenson KE, Rajasagi M, Zhu B, Alonso A, Witten E, Matsuoka K, Neuberg D, Wu CJ, Freeman GJ
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Journal Title
Cancer Immunol Immunother
Volume: 62
Pages: 347-57
DOI
Peer Reviewed
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[Journal Article] Induction of antitumor immunity ex vivo using dendritic cells transduced with fowl pox vector expressing MUC1, CEA, and a triad of costimulatory molecules (rF-PANVAC)2012
Author(s)
Vasir B, Zarwan C, Ahmad R, Crawford K, Rajabi H, Matsuoka K, Rosenblatt J, Wu Z, Mills H, Kufe D, Avigan D
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Journal Title
J Immunotherapy
Volume: 35(7)
Pages: 555-69
DOI
Peer Reviewed
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