2013 Fiscal Year Final Research Report
Evaluation of the expression of transcription factors in pathogenesis of autoimmune arthritis
| Project/Area Number |
24790988
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KONDO Yuya 筑波大学, 医学医療系, 講師 (40612487)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 関節リウマチ / IL-17 / RORγt / Foxp3 / ケモカイン |
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| Research Abstract |
We have examined the role of tanscription factors controlling the differentiation of CD4+ T cells in the development of autoimmune arthritis. In the analyses in mouse model of autoimmune arthritis, we showed that Th-17 specific master transcrption factor RORgt expressing Foxp3+ regulatory T cells might inhibit the development of autoimmune arthritis. In human studies, we observed that RORgt highly expresess in CD4+ T cells isolated from pelipheral blood in patients with rheumatoid arthritis compared with that in healthy controls.
Our results suggested the possibility that control of the expression of transcription factors in CD4+ T cells might be a novel tharapeutic strategy in autoimmune arthritis.
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