2013 Fiscal Year Final Research Report
Effect of intra-articular injection of MCP-1 on arthritis
Project/Area Number |
24790995
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Kanazawa University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | リウマチ学 |
Research Abstract |
Previously, we reported that ablation of an inflammatory chemokine receptor, CCR2, led to aggravation of the arthritis of IL-1ra-/- mouse. We assume that MCP-1, the ligand of CCR2, may resolve the arthritis in IL-1ra-/- and injected repeatedly 100pg of MCP-1 into the joint of IL-1ra-/- mouse. Unexpectedly, more severe arthritis was observed after injection of MCP-1, accompanying severe accumulation of neutrophils and macrophages into the joint. Multiplex analysis of cytokine levels in the joint of mature IL-1ra-/-CCR2-/-mouse (20-week-old) revealed decreased levels of regulatory cytokines, such as IL-4 and IL-10, indicating regulatory roles of macrophages during late stage of arthritis. Collectively, CCR2+ macrophages may serve as pro-inflammatory during early stage and later, as anti-inflammatory during late stage of arthritis.
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[Presentation] アダリムマブ投与有効例, 無効例, 再発例における血中サイトカイン濃度の変化2014
Author(s)
藤井 博, 藤澤 雄平, 北田 欽也, 鈴木 康倫, 伊藤 清亮, 水島 伊知郎, 濱野 良子, 山田 和徳, 山岸 正和, 川野 充弘
Organizer
第58回日本リウマチ学会総会・学術集会
Place of Presentation
東京
Year and Date
20140424-26