Role of Bv8 in rheumatoid arthritis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791007
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Jikei University School of Medicine
• Principal Investigator: NODA Kentaro 東京慈恵会医科大学, 医学部, 助教 (30547914)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 関節リウマチ / Bv8

Outline of Final Research Achievements

1)We studied the Bv8mRNA expression of leukocyte in the patient of rheumatoid arthritis(RA). Bv8mRNA expression was elevated in leukocyte of RA patients, especially in high disease activity patients, suggesting that Bv8 may be a marker of disease activity in RA patients.
2) We examined the expression of prokineticin receptor in collagen induced arthritis(CIA) mice and whether Bv8 recruits polymorphonuclear neutrophils (PMNs) and monocytes in vitro and induces inflammatory arthritis in vivo. Prokineticine receptor 2(PKR2) mRNA expression was elevated in CIA mice. Bv8 recruited PMNs in vitro and induced neutrophil-driven inflammatory arthritis. Bv8 may have a previouslly unrecognised pathogenesis in RA by recruiting PMNs. Targeting Bv8 may provide a new therapeutic strategy to treat rheumatoid arthritis.

Free Research Field

関節リウマチ