2014 Fiscal Year Final Research Report
Effect of S1P/S1P1 signaling on bone destruction in rheumatoid arthritis
| Project/Area Number |
24791014
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 関節リウマチ / スフィンゴシン1リン酸 |
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| Outline of Final Research Achievements |
Sphingosine 1-phosphate (S1P) / S1P receptor 1 (S1P1) signaling plays an important role in synoviocyte proliferation and inflammatory gene expression in rheumatoid arthritis (RA). In the present study, we investigate the role of the S1P/S1P1 signaling on bone destruction in RA. As a results, S1P/S1P1 signaling enhanced RANKL mRNA expression by RA synovial cell line (MH7A cells) and CD4+ T cells. On the other hands, S1P/S1P1 signaling enhanced Runx-2 mRNA expression, ALP activity and osteocalcin production by osteoblast cell line (C2C12 cells). S1P has a dual potential which promotes both osteoclastogenesis and osteoblastogenesis. Taken together, S1P/S1P1 signaling is the important factor which involves bone homeostasis of RA.
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| Free Research Field |
関節リウマチ
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