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2013 Fiscal Year Final Research Report

Live-imaging of Pneumococci and immune-cells in lung.

Research Project

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Project/Area Number 24791024
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionYamaguchi University

Principal Investigator

OGINO Hidetaka  山口大学, 医学(系)研究科(研究院), 助教 (80589325)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords感染症 / 免疫細胞
Research Abstract

Pneumonia is the leading cause of death in children worldwide.
In the causing agent of pneumonia, Streptococcus pneumoniae is the major pathogenic bacterium. Pneumonia caused by bacteria can be treated with antibiotics. However antibiotic-resistant S. pneumoniae is appeared recently, and the antibiotic treatment is becoming difficult. For preventive measures to pneumonia, the vaccination is important.
In this study, we tried to uncover the nature of pneumococci and immune-cells at lung in living body with or without pneumococcal-vaccine. For live imaging at lung, we developed the brighter fluorescent pneumococci. The fluorescent pneumococci were colonized at pulmonary alveoli, and some were flown in the blood vessel. The fluorescent immune-cells is going to be injection into the pneumococci infected mouse, and the phagocytosis of pneumococci by immune-cells is going to be observed. In future, the effect of vaccination to the immunological response will be uncovered.

  • Research Products

    (4 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Crucial role for CD69 in the pathogenesis of dextran sulphate sodium-induced colitis2013

    • Author(s)
      Hasegawa A, Iwamura C, Kitajima M, Hashimoto K, Otsuyama K, Ogino H, Nakayama T and Shirai M
    • Journal Title

      PLoS ONE

      Volume: 8巻 Pages: e65494

    • DOI

      10.1371/journal.pone.0065494

    • Peer Reviewed
  • [Presentation] 腸炎の誘導におけるCD69の役割2014

    • Author(s)
      長谷川 明洋, 荻野 英賢, 大津山 賢一郎, 中山 俊憲, 白井 睦訓
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      20140326-28
  • [Presentation] 肺炎球菌高発現プロモーターの探索2013

    • Author(s)
      荻野 英賢, 長谷川 明洋, 大津山 賢一郎, 白井 睦訓
    • Organizer
      第66回日本細菌学会中国・四国支部総会
    • Place of Presentation
      広島国際大学呉キャンパス(呉)
    • Year and Date
      20131012-13
  • [Presentation] アレルギー性炎症反応におけるリンパ球浸潤に関与する分子の探索2013

    • Author(s)
      長谷川 明洋, 荻野 英賢, 大津山 賢一郎, 中山 俊憲
    • Organizer
      第22回日本バイオイメージング学会学術集会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      20130915-16

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Published: 2015-06-25  

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