2014 Fiscal Year Final Research Report
Elucidation of multiantifungal resistance mechanisms in pathogenic fungi and evaluation of clinical significance
| Project/Area Number |
24791027
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Infectious disease medicine
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
MIYAZAKI Taiga 長崎大学, 医歯薬学総合研究科(医学系), 講師 (60448496)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 薬剤耐性 |
|---|
| Outline of Final Research Achievements |
Considering the limitations of the currently available antifungals, emergence of multiantifungal resistance poses a serious concern in clinical settings. Recent surveillance data have revealed an increased number of Candida glabrata clinical isolates that display resistance to not only azoles but also echinocandins. In this study, we discovered that a single amino acid substitution in gene X confers multiantifungal resistance without affecting virulence in C. glabrata and revealed molecular mechanisms of this phenomenon.
|
| Free Research Field |
医真菌学
|
