2014 Fiscal Year Final Research Report
Mechanism of cyclooxygenase inhibitors that attenuate anti-Candida activity of antifungal agents.
Project/Area Number |
24791032
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Infectious disease medicine
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Research Institution | Osaka City University (2014) National Institute of Infectious Diseases (2012-2013) |
Principal Investigator |
KANEKO YUKIHIRO 大阪市立大学, 医学(系)研究科(研究院), 教授 (90469958)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 感染症治療学 / 新規治療開発 |
Outline of Final Research Achievements |
Fungus is one of rare pathogens but causes intractable infections when they occur in immunocompromised patients. Antifungal agents are limited and combination with some other drugs might modulate its antifungal activity. We showed that anti-pyretic agents, cyclooxygenase (cox) inhibitors, attenuated the antifungal activity. We analyzed how cox inhibitors attenuated the antifungal activity and suggested that cox inhibitors induced an efflux pump which pump out some antifungal agents. This result could be a clue to invent new strategies against fungal infections.
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Free Research Field |
内科学、感染症
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