2013 Fiscal Year Final Research Report
The mechanism for secretory IgA antibody induction by TLR3 ligand
| Project/Area Number |
24791035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
AINAI Akira 国立感染症研究所, インフルエンザウイルス研究センター, 主任研究官 (10572133)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 合成二本鎖RNA / アジュバント / 経鼻インフルエンザワクチン / 感染症 |
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| Research Abstract |
Synthetic double-stranded RNAs, TLR3 agonists, are known to be mucosal adjutant to induce virus-specific secretory IgA antibodies in intranasal vaccination against influenza virus infection. On the other hand, TLR7 agonists may be mucosal adjuvants for intranasal vaccination, since influenza viral RNAs are recognized by TLR7 in a natural infection with influenza virus. However, mucosal adjuvant activities of TLR7 agonists were inferior to those of TLR3 agonists.
At present, the mechanism for secretory IgA antibody induction by synthetic double-stranded RNAs as mucosal adjuvants is continuously investigated.
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[Journal Article] Analysis of bronchoalveolar lavage fluid in a mouse model of bronchial asthma and H1N1 2009 infection2013
Author(s)
Okada S, Hasegawa S, Hasegawa H, Ainai A, Atsuta R, Ikemoto K, Sasaki K, Toda S, Shirabe K, Takahara M, Harada S, Morishima T, Ichiyama T
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Journal Title
Cytokine
Volume: 63(2)
Pages: 194-200
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[Journal Article] Characterization of neutralizing antibodies in adults after intranasal vaccination with an inactivated influenza vaccine2012
Author(s)
Ainai A, Tamura S, Suzuki T, Ito R, Asanuma H, Tanimoto T, Gomi Y, Manabe S, Ishikawa T, Okuno Y, Odagiri T, Tashiro M, Sata T, Kurata T, Hasegawa H
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Journal Title
J Med Virol
Volume: 84(2)
Pages: 336-44
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[Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development2012
Author(s)
Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H, Tanaka T, Saito M, Sugiyama M, Fukuda Y, Ohta T, Sato K, Ainai A, Suzuki T, Hasegawa H, Toyama-Sorimachi N, Kohara H, Nagasawa T, Kaisho T
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Journal Title
Blood
Volume: 120(24)
Pages: 4733-43
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[Presentation] Antibody responses in serum and nasal mucus induced by the intranasal vaccination with a whole-virion inactivated vaccine of A(H5N1) virus in healthy human adults2013
Author(s)
Ainai A, van Riet E, Tamura S, Suzuki T, Kawaguchi A, Ito R, Ikeda K, Senchi K, Asanuma H, Odagiri T, Tashiro M, Kurata T, Hasegawa H
Organizer
7th Vaccine & ISV
Place of Presentation
Barcelona, Spain
Year and Date
20131000
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