The epigenetic control in the vascular lesion formation of pulmonary hypertension.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791057
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Mie University
• Principal Investigator: YODOYA Noriko 三重大学, 医学部附属病院, 助教 (40525367)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺高血圧 / エストロゲン / エピジェネティクス

Outline of Final Research Achievements

Recentrly, a new human pulmonary arterial hypertention (PAH)-like rat model, which mimic pulmonary vasculopathy in human PAH, was reported.Since estorogen has been implicated in the pathogenesis of PAH and epigenetic modification of gene expression, we examined the vascular lesion formation of PAH under the estrogen administration with the rats. In the group received the estrogen before exhibiting PAH, vascular lesions were suppressed, but not in the group received estrogen after exhibited PAH. We found that estrogen was involved in the pathogenesis of PAH and the timing of administration of estrogen was important.
We attempted to separate cultures of smooth muscle cells from each level of the lung vessel and established culture method. This enables the study of cell level to elucidate the pathogenesis mechanisms.

Free Research Field

小児科学