Effect of TGF-beta 1 eluting graft on pulmonary circulation in congenital heart disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791067
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: SAKATA Miho 徳島大学, 大学病院, 特任助教 (80532514)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺血管 / 肺高血圧 / TGF-β1 / 先天性心疾患

Outline of Final Research Achievements

Hypoplastic pulmonary artery and pulmonary circulatory disturbance induce the poor prognosis in children with congenital heart disease. Pulmonary arterial hypertension shows the intima/media hyperplasia. These condition results in severe heart failure. In this study, we’d tried to invent the novel TGF-beta 1 eluting expanded polytetrafluoroethylene graft to prevent the pulmonary arterial pathological change. The administration of TGF-beta 1 inhibits the pulmonary smooth cell proliferation and migration. It did not make the pulmonary artery pressure decreased.

Free Research Field

小児循環器