Investigation into risk factors of pulmonary hypertension in Down syndrome

2015 Fiscal Year Final Research Report

• Project/Area Number: 24791092
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Osaka Medical College
• Principal Investigator: Kishi Kanta 大阪医科大学, 医学部, 助教 (20408503)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: ダウン症候群 / 肺高血圧

Outline of Final Research Achievements

Down syndrome with congenital heart diseases has potential for early development of pulmonary hypertension. Dysregulation of bone marrow protein (BMP)2 signaling is responsible for pulmonary hypertension. In the current study, we examined the relationship between BMP2 signaling and Down syndrome related proteins including dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) and regulator of calcineurin (RCAN)1. In vitro study, BMP2 signaling affected expression of DYRK1A. This finding suggests the relationship between BMP2 signaling and DYRK1A. Further study will be needed to clarify this issue.

Free Research Field

小児循環器