2013 Fiscal Year Final Research Report
Evaluation between Cbr1 copy number resumpsion and several abnormalities in Ts1Cje; a model for Down syndrome
| Project/Area Number |
24791097
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
SHIMOHATA Atsushi 独立行政法人理化学研究所, 脳科学総合研究センター, リサーチアソシエイト (00624735)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ダウン症候群 / 神経科学 / モデルマウス / 行動試験 |
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| Research Abstract |
The present study was designed to evaluate whether the copy number resumption of Cbr1 gene located on DS critical region might rescue phenotypes seen in Ts1Cje:a model mouse for DS. We prepared and analyzed the Ts1Cje/Cbr1(+/+/-) mice in which Cbr1 gene only is set back to a normal expression level. We found that Cbr1 gene was not directly involved in neither decreasing of Body weight, hyper activity and ventricular enlargement in Ts1Cje. However, its possible implication in learning and memory deficit or oxidative stress increase in Ts1Cje remains elusive. We should continue our assessment of gene copy number resumption and their potential rescue of Ts1Cje abnormalities.
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