2013 Fiscal Year Final Research Report
Experiments for fetal programming by embryonic ultrasound cardiography of mice
Project/Area Number |
24791114
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Embryonic/Neonatal medicine
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Research Institution | Fukushima Medical University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Keywords | 胎児プログラミング / 血流再分配 |
Research Abstract |
I gave mice in early pregnancy stress such as the drug load and examined an embryonic heart hemodynamic change by performing embryonic ultrasound cardiography. Heart rate , fractional shortening, and cardiac output tended to increase by subcutaneous injecting 0.2 mg/kg of nicotine to a pregnant mice 15-30 minutes after the injection. On the other hand in embryos, carotid artery flow significantly decreased after nicotine injection in comparison with the control group that injected normal saline , and dorsal aorta and umbilical artery flows tended to decrease 15-30 minutes after the injection.This circulation adjustment is a reaction to lead to the blood flow redistribution, and is considered to influence the fetal programming such as an embryonic growth retardation or postnatal developmental disorders.
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