2014 Fiscal Year Final Research Report
The Role of Annexin in Pregnant woman
| Project/Area Number |
24791117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
MATSUMOTO Makiko 大阪市立大学, 医学(系)研究科(研究院), 登録医 (50599298)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Annexin A2 / 胎盤 / 妊娠高血圧症 |
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| Outline of Final Research Achievements |
The underlying pathogenic mechanism of preeclammpsia(PE) remains unclear. It is thought to be associated with uteroplacental ischemia and endothelial dysfunction. Annexin A2,including syncytiotrophoblasts, is a member of Annexin family.
Placental expression of Annexin A2 as determined by immunohistochemistry was signifiantly higher in PE groups compared with the uncompliated pregnancy group. Placental Annexin A2 mRNA expression was significantly elevated in group 2(PE cases with acute worsening of symptoms necessitating immediate pregnancy termination) compared with the normal pregnancy group and group 1(PE cases without emergency termination of pregnancy).
These fidings suggest that worsening of PE might alter Annexin A2 expression at the transcription level.
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| Free Research Field |
産科
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