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2013 Fiscal Year Final Research Report

Comprehensive analysis of the gene expression changes related to cytomegalovirus infection in the placenta

Research Project

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Project/Area Number 24791126
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

YAMADA Souichi  国立感染症研究所, ウイルス第一部, 主任研究官 (10514119)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords胎盤 / サイトメガロウイルス / モルモット
Research Abstract

Human cytomegalovirus (HCMV) infection to pregnant women causes congenital infection to the fetus through the placenta. The virological analysis in placenta was performed using guinea pig and guinea pig CMV (GPCMV) model. In this study, the guinea pig placental tissue culture system and the system of quantitative measurement of changes in the gene in infected guinea pig placenta were established. By the quantitative analysis of the gene expression change in the infected placenta and cultured cell, the gene expression change was associated with the GPCMV infection. A gene expression change was recognized early in infection in the cultured cell.

  • Research Products

    (6 results)

All 2013 2012

All Journal Article (1 results) Presentation (5 results)

  • [Journal Article] Effects of immunization of pregnant guinea pigs with guinea pig cytomegalovirus glycoprotein B viral spread in the placenta2013

    • Author(s)
      Kaede Hashimoto, Souichi Yamada, Harutaka Katano, Saki Fukuchi, Yuko Sato, Minami Kato, Toyofumi Yamaguchi, Kohji Moriishi, Naoki Inoue
    • Journal Title

      Vaccine

      Volume: 31 Pages: 3199-3205

  • [Presentation] ヒトサイトメガロウイルス(HCMV)UL128/130/131A のホモローグであるモルモットCMV GP129/131/133遺伝子群は細胞指向性の決定因子である2013

    • Author(s)
      山田壮一, 橋本楓, 福地早希, 片岡紀代, 片野晴隆, 井上直樹
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20130000
  • [Presentation] モルモット胎盤組織培養系の樹立とウイルス局在解析2012

    • Author(s)
      山田壮一, 福地早希, 金井亨輔, 片野晴隆, 佐藤由子, 井上直樹
    • Organizer
      第27回へルペスウイルス研究会
    • Place of Presentation
      愛知
    • Year and Date
      20120000
  • [Presentation] Effects of cytomegalovirus infection on placenta in a guinea pig model2012

    • Author(s)
      Souichi Yamada, Saki Fukuchi, Kaede Hashimoto, Harutaka Katano, Yuko Sato, Yoshiko Fukui, Naoki Inoue
    • Organizer
      International Federation of Placenta Associations Meeting
    • Place of Presentation
      Hiroshima
    • Year and Date
      20120000
  • [Presentation] Establishment of an ex vivo culturing method for guinea pig placental tissues and analysis of virus spread in the tissue2012

    • Author(s)
      Souichi Yamada, Saki Fukuchi, Kaede Hashimoto, Harutaka Katano, Yuko Sato, Naoki Inoue
    • Organizer
      Congenital Cytomegalovirus Conference 4th
    • Place of Presentation
      USA
    • Year and Date
      20120000
  • [Presentation] モルモット胎盤組織培養系の樹立とウイルス感染動態の解析2012

    • Author(s)
      山田壮一, 橋本楓, 福地早希, 片野晴隆, 佐藤由子, 金井亨輔, 井上直樹
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20120000

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Published: 2015-06-25   Modified: 2015-08-05  

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