2013 Fiscal Year Final Research Report
The importance of mTOR pathway and autophagy mechanism in angiosarcoma survival
| Project/Area Number |
24791133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Toshiya 東北大学, 大学病院, 医員 (30712195)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASAKI Kenshi 東北大学, 大学院・医学系研究科, 准教授 (40294798)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 血管肉腫 / mTOR経路 / オートファジー |
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| Research Abstract |
The purpose of this study is to check the molecular condition of a patient mechanism of angiosarcoma which has poor prognosis. Especially, I expect mTOR course and participation of the automatic fuzzy mechanism in that with a main purpose. After, in 2012, examining the expression of related molecules with the angiosarcoma tissue for immunohistology; in comparison with a normalcy blood vessel wall strong; confirmed that developed, and what was activated constantly particularly an automatic fuzzy system course was suggested. After using a repressor and the automatic fuzzy repressor of the mTOR course in the culture system of the angiosarcoma cell, I confirmed the apoptotic instruction of the neoplastic cell. I confirmed the expression of both courses with the normal skin in 2013. As for these results, the inhibition of both courses suggested the possibility of new treatment of angiosarcoma.
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