2015 Fiscal Year Final Research Report
Influence of RORgammat expression in CD4+ Tcell induction
| Project/Area Number |
24791134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | Th17細胞 / RORgammat / 接触皮膚炎 |
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| Outline of Final Research Achievements |
Mice transplanted with bone marrow stem cells transduced with RORgammat which controls intreleukin-17 producing T cells (Th17) showed reduced contact hypersensitivity reaction. Regulatory T cells (treg) might have some role in this phenotype and indeed, the number of Treg was increased in these mice. On the other hand, these mice developed vitiligo, alopecia, and rectal prolapse after long-term breeding. These phenotypes are considered to be an autoimmune disease and conflict to the result of contact hypersensitivity. Thus, next we attempted to make neuropilin-1 transgenic mice to investigate correlation between Treg activity and these phenotypes. However, we could not get litter mate.
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| Free Research Field |
皮膚科
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