2013 Fiscal Year Final Research Report

Studies on expression regulation of lysophospholid synthesis enzymes by steroids

Research Project

Project/Area Number	24791138
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	The University of Tokyo
Principal Investigator	SUMIDA Hayakazu 東京大学, 医学部附属病院, 助教 (30609706)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	脂質 / リゾリン脂質合成酵素 / ステロイド
Research Abstract	Autotaxin (ATX) is the enzyme responsible for the production of lysophosphatidic acid with diverse functions. This study revealed that mRNA expression level of ATX was decreased by steroid treatment in ATX-expressing cells. Furthermore, decreased serum ATX antigen levels were observed after the initiation of treatment with steroids for patients. The decreased levels recovered during tapering of PSL dose in a dose-dependent manner. In addition, considering the results of experiments using murine epididymal adipose tissue, decrease of serum ATX levels by steroids might be due to the decrease of ATX production from adipose tissue.