2013 Fiscal Year Final Research Report
Regulation of deep vein thrombosis by adhesion molecules
Project/Area Number |
24791139
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Dermatology
|
Research Institution | The University of Tokyo |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Keywords | 深部静脈血栓症 / 炎症細胞浸潤 / sling / 細胞接着分子 |
Research Abstract |
Rolling neutrophils form very unique structure called "sling" at the front of rolling cells, and this structure stabilizes the rolling at high shear stresses. Our data suggest that the behavior of adhesion molecules on sling plays important role in deep vein thrombosis since the migration of inflammatory cells occurs at relatively high shear stresses.
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