2013 Fiscal Year Final Research Report
Anti-IL-6 antibody attenuates TNF-alpha and cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
| Project/Area Number |
24791142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kanazawa University |
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Principal Investigator |
SAITO Yuki 金沢大学, 大学病院, 助教 (90547168)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 虚血再潅流傷害 / 褥瘡 / TNF-α / IL-6 |
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| Research Abstract |
In a mouse model of cutaneous ischemia-reperfusion injury, local administration of anti-IL-6 antibody inhibited expression of TNF-alpha and inducible nitric oxide synthase, and reduced cytotoxicity of them. And we checked the safeness about intradermal injection with anti-IL-6 antibody.From that reason, I suggest that anti-IL-6 antibody treatment might prevent the pressure ulcers.
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