2014 Fiscal Year Final Research Report
Role of phospholipase C epsilon in Ultaviolet induced skin carcinogenesis, skin inflamation, cataract, and psoraiasis
| Project/Area Number |
24791155
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
|
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| Research Institution | Kobe University |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | PLCε / 皮膚炎症 / 皮膚発癌 / 乾癬 |
|---|
| Outline of Final Research Achievements |
In order to examine the role of phospholipase C epsilon (PLCε) in the skin, we created transgenic mice overexpressing PLCε in epidermal keratinocytes(K5-PLCε-TG mouse). The K5-PLCε-TG mice spontaneously developed skin inflammation as characterized by formation of adherent silvery scales. Histologically, acanthuses, neutrophil infiltration in the epidermis, and STAT3 activation in keratinocytes were observed.
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| Free Research Field |
皮膚科学
|
