2013 Fiscal Year Final Research Report
Analysis of expression mechanism of Tissue Factor in pathophysiology of chronic urticaria
| Project/Area Number |
24791158
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 蕁麻疹 / 血液凝固 / Tissue Factor |
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| Research Abstract |
In the plasma of patients of chronic urticaria, the amount of thrombin produced by adding tissue factor (TF) or phosphatidyl serine was increased. It suggested the fact that the enhancement of extrinsic coagulation was associated with the pathophysiology of chronic urticaria. Also, TF was expressed when human umbilical vein endothelial cells were stimulated by histamine or lipopolysaccharide. The TF expression induced by histamine was suppressed by adding histamine H1 receptor antagonist.
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