Role as a prognotic factor of Pict-1 in Skin carcinogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791173
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Jichi Medical University
• Principal Investigator: NARITA Tae 自治医科大学, 医学部, 研究員 (10301061)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PTEN / Pict-1 / p53 / 日光角化症 / 有棘細胞癌

Outline of Final Research Achievements

Pict-1 stabilizes PTEN, regulates the MDM2-p53 pathway. High expression levels of Pict1 are associated poor prognosis of several cancers with wild-type TP53. Solar Keratosis develops squamous cell carcinoma(SCC) in skin, so we studied clinical prognosis of solar keratosis in human with topical imiquimod application. Some clinical parameters, e.g. solitary, multiple, CR, PD, SCC progression were investigated. Immunohistochemical expression of Pict-1 and p53(WT, mutant) revealed imiquimod effective solar keratosis(CR) with higher cytoplasmic and nuclear Pict-1. It decreases imiquimod resistant solar keratosis(PD) and SCC. Weak p53 expression with strong cytoplasmic Pict1 in CR case, and no p53 expression in PD case. Paradoxically, strong p53 expression of SCC, suggesting more mutant p53 in SCC. These result suggests some mechanisms of UV carcinogenesis prevention in epidermis might regulate Pict-1 and p53 expression.

Free Research Field

皮膚腫瘍、分子シグナル伝達