2013 Fiscal Year Final Research Report
Elucidation of pathophysiology of stress vulnerability by cerebrovascular deficits
| Project/Area Number |
24791193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
YOSHIZAKI Kaichi 東北大学, 医学(系)研究科(研究院), 助教 (50393161)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 血管性うつ病 / ストレス脆弱性 / 臨界期 |
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| Research Abstract |
In the present study, we tried to identify critical period for stress vulnerability by cerebrovascular deficits. Mice were subjected to sham or left unilateral common carotid artery occlusion (UCCAO), and were, immediately or after two weeks, exposed to glucocorticoid, a kind of stress hormone, for two weeks. Then the mice were performed behavioral analyses related to depression. In the result, mice with both sham and left UCCAO exhibited depressive-like behavior in sucrose preference test when exposed glucocorticoid for four weeks. Intriguingly mice with left UCCAO exhibited depressive-like behavior when exposed glucocorticoid for last two weeks. These results suggest that there might be critical period for stress vulnerability during chronic phase after cerebrovascular deficits.
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