2013 Fiscal Year Final Research Report
The long-term effect of Methylphenidate on brain function of ADHD children after wash-out period
| Project/Area Number |
24791201
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ADHD / 光トポグラフィー / 塩酸メチルフェニデート / 注意欠如多動性障害 |
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| Research Abstract |
Methylphenidate (MPH) is the most commonly prescribed treatment for Attention Deficit-Hyperactivity Disorder (ADHD). Near-infrared spectroscopy (NIRS) is a noninvasive neuroimaging method that can measure hemodynamic changes in cortical tissue under natural settings. The stop signal task is suitable for detecting dysfunction of response inhibition in ADHD. In this study we aim to detect the long-term effect of MPH on brain function of ADHD children after wash-out period using NIRS during SST. Drug naive ADHD group had lower NIRS signal than healthy control in baseline assessment. However even after MPH washout following a 1-year administration, NAÏVE demonstrated normalised prefrontal activation. Thus, supplementary NIRS serves as an objective biomarker for clinical decisions concerning to stop MPH treatment in children with ADHD.
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[Journal Article] Genetic influences on prefrontal activation during a verbal fluency task in adults : A twin study based on multichannel near-infrared spectroscopy2014
Author(s)
Sakakibara E, Takizawa R, Nishimura Y, Kawasaki S, Satomura Y, Kinoshita A, Koike S, Marumo K, Kono T, Kuwabara H, Ishii-Takahashi A, Kawakubo Y, Kasai K
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Journal Title
Neuroimage
Volume: 85:1
Pages: 508-17
Peer Reviewed
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[Journal Article] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults2013
Author(s)
Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y
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Journal Title
Neuroimage clinical
Volume: 4
Pages: 53-63
Peer Reviewed
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[Presentation] Neuroimaging-aided prediction of the effect of methylphenidate in children with attention deficit hyperactivity disorder-a randomised controlled trial2014
Author(s)
Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Matsubayashi J, Hamada K, Okuhata S, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, Kano Y
Organizer
69th Society of biological psychiatry
Year and Date
20140500
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