2015 Fiscal Year Final Research Report
Analysis of modulatory effects of Pin1 on DARPP-32 function.
| Project/Area Number |
24791220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
HINO MIZUKI 福島県立医科大学, 医学部, 研究員 (80396663)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | DARPP-32 / Pin1 / 統合失調症 / リン酸化 |
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| Outline of Final Research Achievements |
DARPP-32, which is thought to be involved in schizophrenia, controls the protein phosphatase (PP1) and protein kinase A (PKA) in a phosphorylation-dependent manner, and its phosphorylation level is regulated by dopaminergic and glutaminergic stimulations. .
We hypothesize that Pin1 isomerizes phosphorylated DARPP-32 and controls the inhibitory activity of DARPP-32 on PP1 and PKA. We conducted biochemical analysis to examine the hypothesis. We also made in silico analysis to predict the common binding partners of DARPP-32 and Pin1.
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| Free Research Field |
精神医学
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