2013 Fiscal Year Final Research Report

Establishment of an animal model for schizophrenia based on neurodevelopmental hypothesis.

Research Project

Project/Area Number	24791226
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Nara Medical University
Principal Investigator	FUKAMI Shin-ichi 奈良県立医科大学, 医学部, 助教 (90424150)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	統合失調症
Research Abstract	Schizophrenia is a severe disabling disorder of unknown etiology. The neurodevelopmental model postulates that the illness is caused by a combination of genetic factors and environmental disturbances, including prenatal infection, perinatal complication, and so on. Animal models are indispensable tools to gain insights into mechanisms underlying this illness and to assess potential therapeutic actions of new treatments. In this study, we attempt to generate an animal model that reflects the characteristics of patients with schizophrenia using in utero electroporation. Furthermore, we examine the relationship between histological disturbance and environmental insults such as polyI:C administration.

(2 results)