Associated factors with development of alpha-synucleinopathy from idiopathic rapid eye movement sleep behavior disorder

2015 Fiscal Year Final Research Report

• Project/Area Number: 24791235
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Tokyo Medical University
• Principal Investigator: Sakuma Taeko (笹井妙子) 東京医科大学, 医学部, 講師 (70419026)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: レム睡眠行動障害 / REM sleep without atonia / ドーパミンアゴニス / 認知機能 / 脳波 / 周波数 / アルファシヌクレイノパチー

Outline of Final Research Achievements

REM sleep behavior disorder (RBD), characterized by dream enactment behavior and inhibited mustle atonia during REM sleep, has a risk of future development of alpha-synucleinopathy. This study revealed that dopamine agonist was effective on 61.7% of idiopathic RBD and an amount of REM sleep without atonia was associated with the effectiveness. For incidentally detected REM sleep without atonia (RWA) without clinical symptoms (isolated RWA), as high as 14% of individuals with isolated RWA. About 80% of idiopathic RBD patients showed mild cognitive impairment and they also showed decreased fast EEG activity during both wakefulness and REM sleep. Among the patients, slow wave activity during REM sleep was especially associated with cognitive decline.

Free Research Field

臨床神経生理学