2013 Fiscal Year Final Research Report
A clinical application of Near-Infrared Spectroscopy to Modified Electroconvulsive Therapy
| Project/Area Number |
24791242
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 電気けいれん療法 / 光トポグラフィー / うつ病 / 統合失調症 / 言語流暢性課題 / 治療学的バイオマーカー |
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| Research Abstract |
One of the controversial points in using ECT is a lack of specific indicator, so biological marker for therapeutic effect which can be applied to ECT is required. As a means of biological indicator, we adopted near-infrared spectroscopy (NIRS) and measured the therapeutic effect of ECT in Depression and Schizophrenia. We completed Hamilton Rating Scale for Depression and Brief Psychiatric Rating Scale for Schizophrenia. Cerebral blood flow was measured by 22-channel NIRS before and after ECT. The correlation between integral value in NIRS and therapeutic effect of ECT was observed in severe endogenous depression and also in schizophrenia underwent maintenance ECT. However, there was no relation observed between the integral value and therapeutic effect in depressive states occurred by secondary disability of other psychiatric disorders.
To demonstrate the consequence of our report, future study employing more sample size should be verified.
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[Journal Article] Genome-wide associatin study of atypical psychosis.2013
Author(s)
Kanazawa T, Ikeda M, Glatt SJ, Tsutsumi A, Kikuyama H, Kawamura Y, Nishida N, Miyagawa T, Hashimoto R, Takeda M, Sasaki T, Tokunaga K, Koh J, Iwata N, Yoneda H
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Journal Title
American Journal of Medical Genetics Part B Neuropschiatric
Volume: Vol 162 Issue 7
Pages: 679-86
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