A study on regulation of synaptic dopamine concentration by antipsychotic agent

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791249
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Jikei University School of Medicine (2014); National Institute of Radiological Sciences (2012-2013)
• Principal Investigator: KODAKA FUMITOSHI 東京慈恵会医科大学, 医学部, 助教 (10349582)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ドーパミン / ドーパミントランスポーター / 抗精神病薬 / リスペリドン

Outline of Final Research Achievements

We investigated effects of antipsychotic agent risperidone on synaptic dopamine transporter (DAT) density with positron emission tomography (PET) in healthy male subjects. We calculated DAT binding potential (BP) which reflects DAT density after administration of risperidone and placebo. Although we have no statistical differences between DAT BP values after administration of risperidone and placebo, we found significant correlation between rate of change in DAT BP by risperidone and blood concentration of risperidone.

Free Research Field

神経精神薬理学, 神経画像学, 精神医学