Development of the real-time four-dimensional cone beam CT reconstruction technique for interactive radiotherapy

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791261
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: TAKAO Seishin 北海道大学, 医学(系)研究科(研究院), 助教 (10614216)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 放射線治療 / コーンビームCT / 四次元再構成

Research Abstract

We have proposed a novel method for four-dimensional (4D) cone-beam computed tomography (CBCT) reconstruction with real-time tumor tracking technique. In the real-time tumor tracking, a fiducial marker inserted near the tumor is detected in the orthogonal fluoroscopic images. The three-dimensional position of the marker is calculated every 33 msec with an accuracy of 1 mm. According to the position of the marker, projection images can be classified into some phases. Four dimensional CBCT reconstruction is therefore available in each phase. Feasibility of the 4D CBCT reconstruction was evaluated through the experience using the testing machine, which has the same imaging devices in the proton therapy system in Hokkaido University Hospital. Additionally, characteristics of intrafractional baseline shift of tumor motion were analyzed to investigate efficacy of the 4D CBCT reconstruction method. Through the study, the feasibility and efficacy of the 4D CBCT reconstruction was confirmed.

Research Products

• [Journal Article] Integration of a real-time tumor monitoring system into gated proton spot-scanning beam therapy : an initial phantom study using patient tumor trajectory data (2013)
  • Author(s): Matsuura T, Miyamoto N, Shimizu S, Fujii Y, Umezawa M, Takao S, Nihongi H, Toramatsu C, Sutherland K, Suzuki R, Ishikawa M, Kinoshita R, Maeda K, Umegaki K, and Shirato H
  • Journal Title: Med Phys Volume: 40(7) Pages: 071729
  • Peer Reviewed
• [Journal Article] Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning (2012)
  • Author(s): Mizuta M, Date H, Takao S, Kishimoto N, Sutherland KL, Onimaru R, and Shirato H
  • Journal Title: Med Phys Volume: 39(11) Pages: 6791-6795
  • Peer Reviewed
• [Presentation] Development and Commissioning of the Spot Scanning Proton Beam Therapy System (2014)
  • Author(s): Takao S, Toramatsu C, Matsuura T, Nihongi H, Yamada T, Miyamoto N, Shimizu S, Hashimoto T, Onimaru R, Kinoshita R, Onodera S, Umegaki K, and Shirato H
  • Organizer: 1st GI-CoRE Medical Science and Engineering Symposium
  • Place of Presentation: Sapporo
  • Year and Date: 2014-02-23
• [Presentation] Baseline Shift of Intrafractional Lung Tumor Motionin a Real-time Tumor-tracking Radiotherapy (2013)
  • Author(s): Takao S, Miyamoto N, Matsuura T, Shimizu Onimaru R, Katoh N, Inoue T, and Shirato H
  • Organizer: American Society for Radiation Oncology 55th Annual meeting
  • Place of Presentation: Atlanta
  • Year and Date: 20130922-25
• [Presentation] A Mathematical Framework to Select Fractionation Regimen based on Physical Dose Distribution for Proton Therapy (2013)
  • Author(s): Takao S, Mizuta M, Date H, Komiya Y, Sutherland KL, Onimaru R, Shimizu S, and Shirato H
  • Organizer: 52nd Annual Meeting of the Particle Therapy Co-Operative Group
  • Place of Presentation: Essen
  • Year and Date: 20130602-08
• [Presentation] 陽子線治療における高精度位置決め用コーンビームCT の開発 (2013)
  • Author(s): 高尾聖心, 清水伸一, 宮本直樹, 松浦妙子, 寅松千枝, 二本木英明, 山田貴啓, 梅垣菊男, 白土博樹
  • Organizer: 第10回日本粒子線治療臨床研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2013-09-14
• [Book] Computer Simulation and Analysis of Three-Dimensional Tumor Geometry in Radiotherapy, Applied Biological Engineering - Principles and Practice (2012)
  • Author(s): Takao S, Tadano S, Taguchi H, and Shirato H
  • Total Pages: 29-46
  • Publisher: Intech
• [Patent(Industrial Property Rights)] 放射線治療システム (2013)
  • Inventor(s): 清水伸一, 高尾聖心, 宮本直樹, 松浦妙子, 梅川徹, 平本和夫, 馬場理香, 佐々木淑江, 長峯嘉彦
  • Industrial Property Rights Holder: 北海道大学, 株式会社日立製作所
  • Industrial Property Rights Type: 特許権
  • Industrial Property Number: 特願2013-162656
  • Filing Date: 2013-08-05