2013 Fiscal Year Final Research Report

The study of radiosensitive effect through delatation of tumor vessels with nitroglycerin

Research Project

Project/Area Number	24791266
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Hirosaki University
Principal Investigator	HIROSE Katsumi 弘前大学, 医学(系)研究科(研究院), 助教 (60623767)
Project Period (FY)	2012-04-01 – 2014-03-31
Keywords	ニトログリセリン
Research Abstract	We examined whether nitroglycerin (NTG), which is a effective vasodilator, have an influence on radiosensitivity of cancers through reoxygenation of tumor tissue. The concentration allowable to a livingbody of NTG presented no radiosensitivity in A549 cells, although NTG increased the expression of HIF1alpha and ATM proteins. This study suggested that intracellular reactive oxygen species, including nitric oxide induced by NTG, are involved with megakaryocytopoiesis of K562 chronic leukemia cells. The administration of NTG just before irradiation of 10 Gy presented no radisensitivity on SAS tumor xenograft mouse model. However, NTG increased partial oxygen pressure of the tumor tissue slowly and transiently without the change of the tumor blood flow.