2014 Fiscal Year Final Research Report
MRI-based morphological brain analysis in a rat model of Parkinson's disease and preclinical trials of neurotrophic factors
| Project/Area Number |
24791271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 神経科学 / ラット / VBM / 輪回し運動 / パーキンソン病 |
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| Outline of Final Research Achievements |
Using the high-resolution T2-weighted bran images in rats, our laboratory developed the tissue prior probability maps that include the segmentations of gray matter, white matter, and cerebrospinal fluid. These tissue probability maps enable us to perform voxel-based morphometry (VBM) that has been widely used in human studies. We applied the VBM method to the rat models of Parkinson’s disease, wheel running exercise, cardiopulmonary resuscitation, and heart failure, exemplifying the utility of VBM method in the preclinical rodent studies.
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| Free Research Field |
小動物MRI
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