2014 Fiscal Year Final Research Report
Effects and molecular mechanisms of glioblastoma cell motility in carbon ion beam irradiation
Project/Area Number |
24791275
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Radiation science
|
Research Institution | Gunma University |
Principal Investigator |
YOSHIDA Yukari 群馬大学, 重粒子線医学推進機構, 助教 (90431717)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 遊走 / 脳腫瘍 / 炭素イオン線 |
Outline of Final Research Achievements |
We investigated the relationship between cell invasion and irradiation. Human glioblastoma (GBM) cell lines were irradiated with X-rays or carbon ion beams(C-ions). Not only X-rays but C-ions irradiation increased cell motility at 24 hours after irradiation. C-ions irradiated cells were more migrative than X-rays irradiated cells. Increase of cell migration by irradiation was linear energy transfer (LET)-independent manner. Suppression of O6-methylguanine-DNA methyltransferase (MGMT) expression increased migration of GBM cells. These results suggest that depletion of MGMT is associated with increased cell migration.
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Free Research Field |
放射線生物学
|