2014 Fiscal Year Final Research Report
Radiation-induced HIF-1 alpha is associated with radiation resistance in glioblastoma cells.
| Project/Area Number |
24791277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
SHIRAI Katsuyuki 群馬大学, 医学(系)研究科(研究院), 講師 (10400748)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | HIF-1α / 神経膠芽腫 / radiation |
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| Outline of Final Research Achievements |
Glioblastoma is one of the most radioresistant tumors and the patients have poor prognosis. Hypoxia inducible factor-1α (HIF-1α), molecular markers of hypoxia, has been reported to be associated with radioresistance. We demonstrated that radiation-induced HIF-1α increases PDK1 expression in glioblastoma cells. In the future, this mechanism will be evaluated in vivo model.
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| Free Research Field |
放射線生物学
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