Subtype classification of hepatocellular carcinoma by Gd-EOB-DTPA enhanced magnetic resonance imaging

2013 Fiscal Year Final Research Report

• Project/Area Number: 24791281
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KITAO Azusa 金沢大学, 大学病院, 助教 (20608690)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 肝細胞癌 / subtype / MRI / Gd-EOB-DTPA

Research Abstract

On the hepatobiliary phase of Gd-EOB-DTPA enhanced MR imaging (EOB-MRI), hepatocellular carcinoma (HCC) commonly shows hypointensity, however, a part of HCCs demonstrates hyperintensity caused by over-expression of OATP8, the uptake transporter of Gd-EOB-DTPA. We analyzed the correlation between the biological features and signal intensity on EOB-MRI in surgically resected HCC.
Hyperintense HCC showed significantly less malignant biological features and better prognosis than those of hypointense HCC. Hyperintense HCC, namely OATP8 over-expressed HCC, is supposed to be a subtype with mature hepatocyte like molecular backgrounds.

Research Products

• [Journal Article] Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma (2014)
  • Author(s): Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S
  • Journal Title: Hepatology Volume: (Epub ahead of print)
  • DOI: 10.1002/hep.27093
  • Peer Reviewed
• [Journal Article] Hypervascular hepatocellular carcinomas showing hyperintensity on hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging : a possible subtype with mature hepatocyte nature (2013)
  • Author(s): Yoneda N, Matsui O, Kitao A, Kita R, Kozaka K, Koda W, Kobayashi S, Gabata T, Ikeda H, Nakanuma Y
  • Journal Title: Jpn J Radiol Volume: 31 Pages: 480-90
  • DOI: 10.1007/s11604-013-0224-6
  • Peer Reviewed
• [Journal Article] Hypervascular hepatocellular carcinoma : correlation between biologic features and signal intensity on gadoxetic acid-enhanced MR images (2012)
  • Author(s): Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Gabata T, Yamashita T, Kaneko S, Nakanuma Y, Kita R, Arii S
  • Journal Title: Radiology Volume: 265 Pages: 780-9
  • DOI: 10.1148/radiol.12120226
  • Peer Reviewed
• [Presentation] ミニレクチャー : OATP1B3陽性肝癌(EOB-MRI肝細胞相高信号肝癌) (2014)
  • Author(s): 北尾 梓
  • Organizer: 第20回肝血流動態・機能イメージ研究会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 20140215-16
• [Presentation] Gd-EOB-DTPA造影MRIの分子病理学的背景-肝細胞癌におけるトランスポーター発現を中心に- (2014)
  • Author(s): 北尾 梓.
  • Organizer: 第49回滋賀MRI研究会
  • Place of Presentation: クサツエストピアホテル(滋賀県)
  • Year and Date: 2014-02-07
• [Presentation] 肝悪性腫瘍の画像診断 (2013)
  • Author(s): 北 尾 梓
  • Organizer: Advanced Imaging Multimodality Seminars Abdominal Imaging 2013
  • Place of Presentation: ベルサール汐留(東京都)
  • Year and Date: 20131005-06
• [Presentation] Hypervascular Hepatocellular Carcinoma Showing Hyperintensity on Hepatobiliary Phase of Gadoxetic Acid Enhanced MR Imaging : A Less Malignant Subtype with Low Production of AFP and PIVKA-II (2013)
  • Author(s): Azusa Kitao, et al
  • Organizer: American Roentgen Ray Society annual meeting 2013
  • Place of Presentation: Washington Marriott Wardman Park (USA)
  • Year and Date: 20130414-19
• [Presentation] ランチョンセミナー : Gd-EOB-DTPA造影MRIによる多血性肝細胞癌のsubtype分類-高信号肝細胞癌の特徴を中心に- (2013)
  • Author(s): 北尾 梓
  • Organizer: 第72回 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 20130411-14
• [Presentation] Gd-EOB-DTPA 造影MRI肝細胞相で高信号を呈する多血性肝細胞癌 : 造影CT およびMRI 所見の特徴 (2013)
  • Author(s): 北尾 梓, 他
  • Organizer: 第72回 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 20130411-14
• [Presentation] シンポジウム : Gd-EOB-DTPA造影MRI肝細胞造影相で高信号を呈する肝細胞癌の生物学的特徴の検討 (2013)
  • Author(s): 北 尾 梓, 他
  • Organizer: 第19回 肝血流動態イメージ研究会
  • Place of Presentation: 東京ビッグサイト(東京都)
  • Year and Date: 20130126-27
• [Presentation] 教育講演 : EOB-MRI肝細胞相で等・高信号を呈する多血性結節をどう考えるか? (2013)
  • Author(s): 北尾 梓
  • Organizer: 第13回関西肝血流動態イメージ研究会
  • Place of Presentation: オーバルホール(大阪府)
  • Year and Date: 2013-07-27
• [Presentation] Gd-EOB-DTPA造影MRI肝細胞造影相で高信号を呈する多血性肝細胞癌 : 発癌様式の検討 (2013)
  • Author(s): 北尾 梓, 他
  • Organizer: 第49回日本肝癌研究会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2013-07-12
• [Presentation] Gd-EOB-DTPA造影MRIによる肝細胞癌診断-トランスポーターの発現を中心に- (2013)
  • Author(s): 北尾 梓
  • Organizer: Advanced CT・MR 2013
  • Place of Presentation: 軽井沢プリンスホテル(長野県)
  • Year and Date: 2013-06-16
• [Presentation] Hepatocellular carcinoma : Correlation between gadoxetic acid enhanced MR imaging and uptake transporter OATP8 expression (2012)
  • Author(s): Kitao A, et al
  • Organizer: Radiological Society of North America 2012
  • Place of Presentation: McCormick Place, Chicago (USA)
  • Year and Date: 20121125-30
• [Presentation] ワークショップ : Gd-EOB-DTPA造影MRI 肝細胞相で高信号を呈する肝細胞癌-分子病理学的特徴とsubtype 分類の提唱- (2012)
  • Author(s): 北尾 梓, 他
  • Organizer: 第48回 肝癌研究会
  • Place of Presentation: 金沢石川県立音楽堂(石川県)
  • Year and Date: 20120720-21
• [Presentation] シンポジウム : 肝細胞癌におけるGd-EOB-DTPA の取り込みおよび排泄に関与するトランスポーター (2012)
  • Author(s): 北尾 梓, 他
  • Organizer: 第48回 肝癌研究会
  • Place of Presentation: 金沢石川県立音楽堂(石川県)
  • Year and Date: 20120720-21
• [Presentation] The uptake transporter OATP8 expression decreases during hepato- carcinogenesis : correlation with Gd-EOB-DTPA enhanced MR imaging (2012)
  • Author(s): Kitao A, et al
  • Organizer: American Roentgen Ray Society annual meeting 2012
  • Place of Presentation: Vancouver convention centre (Canada)
  • Year and Date: 20120429-0504
• [Presentation] Gd-EOB-DTPA 造影MRI肝細胞造影相で高信号を呈する肝細胞癌 : 腫瘍マーカー産生を中心とする生物学的特徴の検討 (2012)
  • Author(s): 北尾 梓, 他
  • Organizer: 第71回 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 20120412-15