2013 Fiscal Year Final Research Report
Enhancing anti-tumor effect of I-131 MIBG therapy for neuroblastoma by inhibition of cell recovery
| Project/Area Number |
24791285
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 神経芽腫 / 内用療法 / カフェイン |
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| Research Abstract |
I-131 meta-iodobenzylguanidine (MIBG) has been used to treat patients with high-risk neuroblastoma. I-131 MIBG accumulate into tumor cells and has an anti-tumor effect by high-energy beta-irradiation. Caffeine is classified as purine alkaloids, and has anti-tumor effect in tumor cells by inhibition of DNA-repair. This study was performed whether I-131 MIBG interacted with caffeine for human neuroblastoma cell line SK-N-SH. Cells were treated with caffeine at concentrations as high as 40 mM, and the anti-tumor effect of caffeine was concentrate-dependent. However, uptake of I-131 MIBG into neuroblastoma cells treated by caffeine was reduced independently of the load timing. These results suggest that high-dose caffeine has anti-tumor effect, but the anti-tumor effect by combined I-131 MIBG and caffeine will not be enhanced, probably by decreasing uptake of I-131 MIBG.
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