2013 Fiscal Year Final Research Report
A development of Tumor imaging by I-123 Lactsome using small animal SPECT/CT
| Project/Area Number |
24791298
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
KURIHARA Kensuke 京都大学, 医学(系)研究科(研究院), 助教 (90531997)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ナノキャリア / ミセル / SPECT-CT / EPR効果 / 腫瘍イメージング / ABC現象 / 転移モデル |
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| Research Abstract |
We aimed at a development of the nanocarrier called Lactsome who is able to diagnose carcinoma. The study of small animal SPECT imaging was performed by using the Lactsome labeled by I-123 or In-111. We repeated improvement of Lactsome, with establishing of various labeled Lactsome and obtaining fluorescent imaging by ICG labeled Lactsome, and performing the biodistribution. As a result, we finally obtained excellent small animal SPECT imaging by using the Lactsome which is called S50-A3B type and labeled by In-111-DOTA. However, there is left many tasks, such as reduction the accumulation to liver and spleen, the suppression of an ABC phenomenon completely, and so on.
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