Development of novel 68Ga labeled tumor imaging agents based on cell trapping mechanism.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791316
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagasaki University
• Principal Investigator: FUCHIGAMI Takeshi 長崎大学, 医歯学総合研究科(薬学系), 准教授 (30432206)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PET / 68Ga / ジェネレータ / 腫瘍 / 葉酸受容体

Outline of Final Research Achievements

We aimed to develop novel 68Ga labeled tumor imaging agents which can be produced without cyclotron. We have designed, synthesized and evaluated 68Ga labeled agents targeting folate receptor (FR), which can be internalized by cell trapping. We synthesized a FR agonist based 67Ga-NOTA-NCS-FL and an antagonist based 67Ga-NOTA-NCS-TP. In the saturation binding experiments and in vitro uptake experiments, 67Ga-NOTA-NCS-TP showed higher binding affinity and uptake efficiency than those of 67Ga-NOTA-NCS-FL. Accordingly, 67/68Ga-NOTA-NCS-TP can be a prospective tumor imaging agent targeting FR.

Free Research Field

放射線科学