Biological basic research of Proton therapy using spot scanning method

2014 Fiscal Year Final Research Report

• Project/Area Number: 24791322
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: IWATA Hiromitsu 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (40611588)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: スポットスキャニング法 / 陽子線治療 / 生物学的効果比

Outline of Final Research Achievements

We determined the relative biological effectiveness (RBE) of passive scattering and spot scanning proton beams at the center of the spread-out Bragg peak (SOBP) in multi cell lines. The RBE values of the passive scattering and spot scanning proton beams varied with the cell line, but were in the range reported previously. The RBE value of the spot scanning system was almost identical to that of the passive scattering system.(about 1.1) Since RBE using spot scanning systems may vary with the position in the SOBP, especially at the distal end, further radiobiological investigations are warranted to better understand the efficacy of proton therapy. It seems that the oxygen enhancement ratios of proton beams were significantly lower than those of X rays. Proton therapy seems to offer an advantage against hypoxic cells compared to X-ray treatment.

Free Research Field

放射線治療、粒子線治療